Somatic & Body Based

What is Somatic Unwinding?

Somatic Unwinding is a self-directed somatic practice in which the body moves spontaneously through held tension and habitual patterns while your attention stays with the sensations that arise.

Limited Evidence

Last Updated

4 Jul 2026

We are still reviewing this page. Our research team checks every technique page for accuracy and evidence quality before final release. Details may change as that review completes. The evidence badge shows our current reading of the published research.

RECOMMENDED DOSE

How Much Somatic Unwinding Should You Do?

No direct dose-response literature exists for this technique. This is a conservative introductory range based on general practice conventions for gentle body-based somatic work; start short so you can build a comfortable, sustainable habit. No direct dose evidence; editorial synthesis.

No direct dose-response literature exists for this technique. Once short sessions feel easy, this represents a modest step up in duration and regularity, in line with general somatic-practice conventions. No direct dose evidence; editorial synthesis.

No direct dose-response literature exists for this technique. This maintenance-level range reflects general conventions for an established somatic practice and should be approached only after intermediate sessions feel comfortable. No direct dose evidence; editorial synthesis.

Session length

Session length: 5–10 minutes

MIN

How long each individual practice session should last from start to finish.

Frequency

Frequency: 3–4 days

DAYS

The number of days per week to fit a session into your routine.

Session length

Session length: 15–20 minutes

MIN

How long each individual practice session should last from start to finish.

Frequency

Frequency: 4–5 days

DAYS

The number of days per week to fit a session into your routine.

Session length

Session length: 30–40 minutes

MIN

How long each individual practice session should last from start to finish.

Frequency

Frequency: 5–6 days

DAYS

The number of days per week to fit a session into your routine.

About this card. No direct dose-response literature exists for Somatic Unwinding; these durations and frequencies are editorial starting points based on general conventions for body-based somatic practice, not on studies of this technique. These recommendations are not a substitute for personalised guidance from a qualified practitioner.

Related Techniques to Somatic Unwinding

Vibrational Release

Authentic Movement

Common questions about Somatic Unwinding

Quick answers to what people most often ask. Each card links to the deeper section below.

evidence

What does the research say about Somatic Unwinding?

No high-quality controlled trials have yet tested Somatic Unwinding as a self-directed awareness practice. Its foundations come from craniosacral therapy and myofascial release, hands-on traditions where related techniques see some clinical use. Many people report tension releasing and the body settling, but current research cannot measure effect sizes, duration, or who benefits most.

good for

Who is Somatic Unwinding good for?

Somatic Unwinding may suit people who feel tension lodged in the body, who find deliberate stretching or hands-on handling activating, or who want to rebuild connection with their body at their own pace. It supports tension release, physical ease, body awareness, and grounding, rather than treating any diagnosed condition.

safety

Is Somatic Unwinding safe?

Most healthy adults can practise Somatic Unwinding safely, and the spontaneous trembling that arises usually settles into physical relief. Because the practice can surface intense sensation, emotion, or memory, go gently. People with a trauma history, seizure or movement disorder, acute pain, or recent injury should work with a trained somatic practitioner. No safety-specific trials exist.

how it works

How does Somatic Unwinding work?

Somatic Unwinding is thought to work by pairing sustained, unforced attention with spontaneous movement, allowing the nervous system to complete and release patterns of holding. As tension is contacted, the body may tremble or vibrate, a discharge that gives way to settling, while attention sharpens toward internal signals so early stress cues become easier to catch.

For clinicians, researchers, and curious readers

What's in a session?

How does it work?

What does it do to the body?

What is it used for?

What does the research say?

Where does it come from?

Is it safe?Who should practise with care?How to practise safely?

How does it compare?

What does a Somatic Unwinding session involve?

Somatic Unwinding is a self-directed somatic practice in which the body moves spontaneously through held tension and habitual patterns while you stay aware of the sensations that arise.

You settle into a supported position and bring unforced attention to an area of tension, then allow whatever small movements arise, rotations, stretches, tremors, or positional shifts, to unfold at the body's own pace. Nothing is stretched or corrected on purpose; the practice is client-directed and non-forced, and sessions can be self-guided or supported by a trained somatic practitioner.

Somatic Unwinding is distinct from stretching, which is deliberate and effortful; from Authentic Movement, which emphasizes expressive rather than corrective movement; and from hands-on manual therapy, which is directed by a practitioner. Here the movement is spontaneous and led by the practitioner's own body. Its lineage in craniosacral therapy and myofascial release explains its form, not any clinical effect.

Not to be confused with

Stretching

Stretching deliberately lengthens a muscle toward a target position you choose, holding until you feel a pull. Somatic Unwinding sets no destination and never pushes into a shape, letting the body move spontaneously and change direction at its own pace.

Authentic Movement

Authentic Movement centres free, expressive movement, often witnessed by another person, as a way to explore feeling and imagery. Somatic Unwinding instead follows the body's corrective impulse to release held tension, with attention on physical sensation rather than self-expression.

Somatic Experiencing

Somatic Experiencing is a structured trauma therapy that tracks activation and guides completion of the stress response, usually with a trained therapist. Somatic Unwinding is a narrower self-directed movement practice; it shares the discharge idea but is not a trauma treatment protocol.

How does Somatic Unwinding work?

Somatic Unwinding is thought to work by pairing sustained, unforced attention with spontaneous movement, letting the nervous system complete and release patterns of holding it has been maintaining. As habitual tension is contacted, the body may begin small involuntary movements or tremors, what practitioners call nervous system discharge, which tends to feel like trembling or vibration that gives way to a deep settling, as though the body is finally putting down something it had been carrying. At the same time, attention often sharpens toward internal signals, the tightness, breath, and warmth that make up interoceptive awareness, so the early cues of stress become easier to catch before they build. These mechanisms are drawn from adjacent somatic and bodywork practices rather than measured for Somatic Unwinding specifically, so they describe how the practice is thought to work, not a confirmed pathway.

What does Somatic Unwinding do to the body?

In the body, Somatic Unwinding is linked with releasing muscular tension, softening in braced areas, and slower, deeper breathing as the practice unfolds. As skeletal muscles let go in what is called muscular relaxation, holding areas may feel like they are lengthening and warming, and a wave of physical ease can spread outward. The felt sense of where your body is in space, called proprioceptive awareness, often becomes clearer, leaving a grounded, physically present quality. These changes are inferred from related somatic practices rather than measured directly in Somatic Unwinding, so no specific increases or decreases have been quantified for this technique yet.

What is Somatic Unwinding used for?

Limited–Emerging evidence to date supports Somatic Unwinding, which is used for tension release, physical ease, body awareness, and emotional grounding; these uses rest on its bodywork lineage and on mechanisms studied in adjacent somatic practices rather than on trials of Somatic Unwinding itself. The concept comes from craniosacral therapy and myofascial release, where related manual techniques have some clinical use, though controlled studies of unwinding as a self-directed awareness practice are scarce. What is not yet supported includes large randomized trials, measured effect sizes, long-term follow-up, and any claim that it treats or replaces care for a diagnosed condition.

No Claims Were Provided In The Input To Assess

Some people may feel tension easing and their breath softening as the body moves at its own pace during Somatic Unwinding, a self-directed practice of letting the body move spontaneously through held tension while you stay aware of what you feel. No specific benefit was submitted for this row to assess, and the practice supports rather than replaces professional care.

What does the research say about Somatic Unwinding?

Somatic Unwinding has not yet been tested in high-quality controlled trials as a self-directed awareness practice. Its roots lie in craniosacral therapy and myofascial release, hands-on traditions where related techniques have some clinical use, but the awareness practice described here rests largely on indirect evidence and on mechanisms such as interoceptive awareness, muscular relaxation, and nervous system discharge that are better studied in other somatic and breathwork practices. Many people report a genuine sense of tension releasing and the body settling, and that lived experience is worth taking seriously, though current research cannot yet measure effect sizes, how long benefits last, or who is helped most.

The available material is useful for setting expectations, but methods and participant groups vary across the adjacent practices it draws on. Treat the findings as general guidance rather than a promise about any single session, and not as a replacement for clinical care.

Read the full reference list

Where does Somatic Unwinding come from?

Somatic Unwinding grew out of craniosacral therapy, systematized by John Upledger in the 1980s, and myofascial release, developed by John Barnes, where it describes the body's spontaneous, self-corrective movement through fascial and postural holding patterns. These roots help explain the practice's form, its unforced, client-directed quality and its trust in spontaneous movement, rather than proving any clinical effect. The tradition frames the body as having a self-corrective intelligence, a worldview that makes allowing movement, rather than directing it, central to the practice.

Is Somatic Unwinding safe?

Somatic Unwinding is a low-risk practice for most healthy adults. The spontaneous trembling or shaking that can arise usually settles into a wave of physical relief, a heaviness spreading through the body as held tension lets go. Because the practice allows nervous system discharge, the release of stored activation through involuntary movement, it can also surface intense sensation or unexpected waves of emotion and memory. That caution is drawn from how the technique is used and from what its mechanism would predict, not from a tested safety trial, so go gently and slow down if the experience starts to feel like too much. High-quality controlled research on Somatic Unwinding as an awareness practice is limited, which is why both its benefits and its cautions are described conservatively.

Who should practise with care?

Take extra care if you live with a trauma history. Letting the body move freely can bring up trauma-related memory or strong emotional release, so where you can, work alongside a trained somatic practitioner who can support you if difficult material surfaces. People with a seizure or movement disorder, acute pain, or a recent injury should also proceed slowly, since involuntary movement could aggravate an unstable condition. These cautions come from how the technique is used within craniosacral and myofascial traditions rather than from safety-specific trials, and Somatic Unwinding is not a substitute for medical or mental health care when that care is needed.

Strong sensation or emotional release

lowpractice-informed

Because Somatic Unwinding allows nervous system discharge, the release of stored activation through involuntary trembling or shaking, it can surface intense sensation or unexpected waves of emotion and memory alongside the physical relief. This caution is drawn from how the technique is used and from what its mechanism would predict, not from a tested safety trial. Go gently, and slow down, open your eyes, or feel your contact with the floor if the experience starts to feel like too much.

Trauma history

How does Somatic Unwinding compare to similar techniques?

Technique	Best for	Use with care	Evidence strength	Distinction
Craniosacral therapy and myofascial release	People who want practitioner-guided, hands-on release of fascial restriction and postural holding.	Hands-on contact can feel activating for some trauma survivors, who may prefer self-directed movement.	emerging EVIDENCE	Somatic Unwinding is the self-directed cousin of these hands-on therapies. In craniosacral and myofascial work a practitioner applies gentle contact to guide fascial release, the softening of the connective-tissue webbing that wraps muscle; in unwinding the person follows their own body's spontaneous impulse to move and release, with attention resting on the sensations that surface rather than on a therapist's hands.
Tension and Trauma Releasing Exercises (TRE)	People who want a structured, repeatable way to switch on therapeutic tremoring and discharge.	The strong evoked shaking can overwhelm people with a trauma history or a seizure or movement disorder.

Glossary

Somatic unwinding

Letting the body move by itself through tight or braced areas while you stay aware of what you feel, rather than stretching or correcting on purpose. The movement is self-directed and unforced, unfolding as micro-movements, rotations, and positional shifts at the body's own pace.

Interoceptive awareness

The ability to sense and read internal body signals such as breath movement, heartbeat, tension, and temperature. Growing it tends to feel like being more embodied and noticing early stress signals before they escalate.

Perception and interpretation of visceral and afferent bodily signals, associated with insular cortex processing.

Proprioceptive awareness

A clearer sense of where your body is in space, its position, movement, and orientation, drawn from receptors in muscles, joints, and tendons. It usually feels like better balance, more precise movement, and a grounded, physically present quality.

Nervous system discharge

The release of stored fight-flight-freeze activation through spontaneous trembling, shaking, or involuntary movement. It often feels like a wave of vibration followed by a deep settling, as though the body is finally letting go of tension it has been holding.

Neurogenic or autonomic release that allows completion of interrupted stress-response cycles and a return toward baseline.

Muscular relaxation

The reduction of muscle tension that lets fibres lengthen and soften. It is felt as a tangible letting go, where areas of holding dissolve, breathing deepens, and a spreading wave of physical ease follows.

Fascia and myofascial release

Fascia is the connective-tissue webbing that wraps and links muscles throughout the body; myofascial release is the softening of tightness or restriction in that webbing. As it eases, movement can feel freer and less braced.

Completion of the stress response cycle

The idea that a fight-flight-freeze reaction, once interrupted, can finish itself through movement or trembling so the body resets. It tends to feel like tension moving through and out, leaving a calmer, more settled state.

Full References

[1]other peer reviewed

G. Borg (2019). Perceived exertion as an indicator of somatic stress.. https://doi.org/10.2340/1650197719702239298

DOI: 10.2340/1650197719702239298

Cited in: –

[2]other peer reviewed

Benjamin Gierk, Sebastian Kohlmann, Kurt Kroenke, Lena Spangenberg, Markus Zenger, Elmar Brähler (2013). The Somatic Symptom Scale–8 (SSS-8). https://doi.org/10.1001/jamainternmed.2013.12179

DOI: 10.1001/jamainternmed.2013.12179

Cited in: –

Letting the body move freely can bring up trauma-related memory or strong emotional release. Where you can, work alongside a trained somatic practitioner who can support you if difficult material surfaces, keep sessions short, and ground or open your eyes when things feel like too much. This caution is practice-informed, drawn from craniosacral and myofascial traditions rather than a safety-specific trial, and Somatic Unwinding is not a substitute for mental health care.

Seizure or movement disorder

lowpractice-informed

Somatic Unwinding invites spontaneous, involuntary movement and trembling, which could aggravate an unstable seizure or movement condition. Proceed slowly and work alongside a trained somatic practitioner or your clinician. This caution comes from how the technique is used within craniosacral and myofascial traditions rather than from safety-specific trials, and the practice is a support to, not a replacement for, the medical care you already receive.

Acute pain or recent injury

lowpractice-informed

Because involuntary movement could aggravate an unstable condition, people with acute pain or a recent injury should proceed slowly and treat Somatic Unwinding as a support to, not a replacement for, their care. This caution reflects how the technique is used rather than a tested safety finding, so favour gentleness and stop if movement increases discomfort.

How to practise safely?

Somatic Unwinding is best met with an unhurried attitude, in a quiet space where you have room to move and no reason to rush afterward. For most beginners a gentle session on soft flooring or a supported surface works well, letting any movement stay entirely optional rather than something you make happen. Go slowly, keep your attention with what you actually feel, and know that you can ease off or stop at any point if the experience starts to feel like too much.

Choose a safe, unhurried setting

Practise in a quiet space with room to move and enough time that you never feel rushed. Soft flooring or a supported surface helps, so that spontaneous shifts in position feel safe rather than jarring.

Let movement stay optional

Begin by noticing areas of holding or tension, and allow any micro-movement, rotation, or shift to emerge on its own. Never force or steer it. If nothing arises, resting with awareness is a complete practice in itself.

Keep attention with the sensations

As the body moves, rest your attention on what you actually feel, tightness softening, breath deepening, a clearer sense of where your body is in space. Staying with these internal signals, what practitioners call interoceptive tracking, is what keeps the practice grounded.

Allow trembling or shaking to run its course

If involuntary trembling or vibration begins, let it continue at its own pace rather than stopping or amplifying it. For most people this is followed by a settling and a feeling of tension letting go.

Pause if a reaction becomes overwhelming

When emotion, memory, or sensation rises faster than you can stay with, slow down, open your eyes, feel your contact with the floor, and return to steady breathing. There is no need to push through, and you can stop at any point.

Come back to stillness gradually

Give yourself a few quiet minutes at the end. If you have been lying down or your blood pressure runs low, return to sitting and then standing slowly so you do not feel light-headed.

Seek trained support when it is warranted

If you carry a trauma history, a seizure or movement disorder, acute pain, or a recent injury, practise alongside a trained somatic practitioner or your clinician, and treat Somatic Unwinding as a support to, not a replacement for, the care you already receive.

Medical Disclaimer

This information is educational and is not medical advice. This practice is not a substitute for professional care and should not replace prescribed medication or treatment for any medical or mental-health condition. If you are managing a health condition or taking medication, talk with a qualified health professional before changing your practice. If you are in distress or crisis, seek professional support.

Does somatic unwinding actually work?

Not proven yet. Somatic Unwinding has not been tested in high-quality controlled trials as a self-directed awareness practice, so its benefits cannot be measured or confirmed. Its rationale rests on its craniosacral and myofascial roots and on mechanisms studied in related practices, so any benefit is best treated as individual and exploratory rather than established.

Not proven yet. Direct, well-controlled research on Somatic Unwinding as a self-directed awareness practice is limited, so current evidence cannot measure effect sizes, how long any benefit lasts, or who is helped most. What support exists is indirect: it draws on the practice's craniosacral and myofascial lineage and on mechanisms such as interoceptive awareness, muscular relaxation, and nervous system discharge that are better studied in adjacent somatic and breathwork practices. Many people report a real sense of tension releasing and the body settling, and that lived experience is worth taking seriously, but it remains suggestive rather than confirmed, and Somatic Unwinding is not a substitute for care for a diagnosed condition.

Why does my body start trembling or shaking during somatic unwinding?

Usually it's expected. Trembling is understood as nervous system discharge, the body releasing stored fight-flight-freeze activation through involuntary movement, often followed by a settling. This is inferred from related practices, not measured in Somatic Unwinding itself, so it describes how the practice is thought to work rather than a proven pathway.

Usually it's a normal part of the process, not a warning sign. The trembling or shaking is described as nervous system discharge, the body releasing stored fight-flight-freeze activation through spontaneous involuntary movement, which tends to give way to a wave of settling and physical ease. This mechanism is drawn from adjacent somatic and breathwork practices rather than measured in Somatic Unwinding specifically, so it describes how the practice is thought to work rather than a confirmed or treatment effect. If the shaking ever feels like too much, you can slow down, open your eyes, and feel your contact with the floor.

Is somatic unwinding safe if you have a trauma history?

Use care. For most healthy adults Somatic Unwinding is low-risk, but because free movement and nervous system discharge can surface strong emotion or trauma-related memory, people with a trauma history are best supported by a trained somatic practitioner. Go gently, and you can stop anytime.

Use care. Somatic Unwinding lets the body move spontaneously and can prompt nervous system discharge, the release of stored fight-flight-freeze activation through trembling or shaking, which may bring up intense sensation, emotion, or trauma-related memory. If you carry a trauma history, working alongside a trained somatic practitioner, keeping sessions short, and grounding or opening your eyes when things feel like too much are sensible steps. This caution is practice-informed, drawn from craniosacral and myofascial traditions rather than a tested safety finding, no safety-specific trials exist for this technique, and it is not a substitute for mental health care.

Is somatic unwinding safe if you have a seizure or movement disorder?

Proceed with caution. If you live with a seizure or movement disorder, work with a trained somatic practitioner or your clinician before trying Somatic Unwinding, since its involuntary trembling or shaking could aggravate an unstable condition. This is a practice-informed caution, not a tested safety finding, and it is not a substitute for medical care.

Proceed with caution. Somatic Unwinding invites spontaneous, involuntary movement and trembling, and for someone with a seizure or movement disorder that unpredictable activity could aggravate an unstable condition, so it is safest to go slowly and work alongside a trained somatic practitioner or your clinician. This caution comes from how the technique is used within craniosacral and myofascial traditions rather than from safety-specific trials, so treat it as a sensible precaution rather than an established finding. Somatic Unwinding is a support to, not a replacement for, the medical care you already receive.

How do I start somatic unwinding on my own?

Start in a safe, unhurried space with room to move, notice where your body feels held, and let any small movement emerge on its own without forcing it. Keep your attention on the sensations, let trembling run its course, and pause or open your eyes if anything feels overwhelming.

Begin by choosing a quiet, soft space with enough time that you do not feel rushed. Notice areas of holding and allow micro-movements, rotations, or trembling to arise on their own rather than steering them; simply resting with awareness counts as a complete practice if nothing emerges. Keep attention on what you feel, let any shaking settle at its own pace, and if emotion or sensation rises too fast, slow down, feel the floor, and return to steady breathing. These steps are practice-informed, drawn from bodywork traditions rather than trial-tested instructions, and if you carry a trauma history, a seizure or movement disorder, acute pain, or a recent injury, work alongside a trained somatic practitioner and treat this as a support to, not a replacement for, your care.

What if nothing happens during my first somatic unwinding session?

That's normal. A first session can feel like very little, and simply resting with awareness of what you feel is a complete practice in itself. The sense of unwinding often deepens with repetition rather than arriving all at once, so nothing spontaneous happening is not a sign of doing it wrong.

That's normal, and it doesn't mean you are doing it wrong. Somatic Unwinding invites the body to move spontaneously through held tension while you stay aware of the sensations that arise, so if no movement emerges, staying present with your breath and body is already a full practice. Many people find the felt sense of unwinding builds gradually across sessions rather than in the first one. Because direct research on this practice is scarce, treat what you notice as individual and exploratory rather than a certain outcome with continued practice.

What's the difference between somatic unwinding and TRE?

Both reach nervous system discharge, the release of stored activation through trembling or shaking, but by different routes. TRE (Tension and Trauma Releasing Exercises) deliberately fatigues the muscles through a set sequence to evoke the shaking, while Somatic Unwinding waits for spontaneous, unforced trembling and movement to emerge from sustained awareness.

The core difference is method, not aim. TRE uses a structured, repeatable exercise sequence that fatigues specific muscles to switch on therapeutic tremoring, whereas Somatic Unwinding is self-directed and non-forced: you let micro-movements, rotations, and trembling arise on their own while attention rests on the sensations. Because Somatic Unwinding has not been directly tested in controlled trials as an awareness practice, this is a descriptive distinction between how each practice works, not a claim that one is more effective than the other.

[3]meta analysis

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[4]other peer reviewed

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[5]other peer reviewed

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[8]other peer reviewed

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[9]other peer reviewed

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[10]other peer reviewed

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[11]other peer reviewed

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[12]observational

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[13]other peer reviewed

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[14]other peer reviewed

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[15]other peer reviewed

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[16]other peer reviewed

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[17]other peer reviewed

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[18]observational

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[19]observational

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[20]other peer reviewed

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[21]other peer reviewed

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[22]other peer reviewed

Yuichi Kanehiro, Kagefumi Todo, Misaki Negishi, Junji Fukuoka, Wenjian Gan, Takuya Hikasa (2012). Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1. https://doi.org/10.1073/pnas.1120368109

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[23]other peer reviewed

Élodie Pongan, COVCARE Group, Jean‐Michel Dorey, Céline Borg, Jean Claude Getenet, Romain Bachelet (2021). COVID-19: Association Between Increase of Behavioral and Psychological Symptoms of Dementia During Lockdown and Caregivers’ Poor Mental Health. https://doi.org/10.3233/jad-201396

DOI: 10.3233/jad-201396

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[24]other peer reviewed

Cuiyan Wang, Riyu Pan, Xiaoyang Wan, Yilin Tan, Linkang Xu, Cyrus S. H. Ho (2020). Immediate Psychological Responses and Associated Factors during the Initial Stage of the 2019 Coronavirus Disease (COVID-19) Epidemic among the General Population in China. https://doi.org/10.3390/ijerph17051729

DOI: 10.3390/ijerph17051729

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[25]other peer reviewed

Mara Naegelin, Raphael P. Weibel, Jasmine I. Kerr, Victor R. Schinazi, Roberto La Marca, Florian von Wangenheim (2023). An interpretable machine learning approach to multimodal stress detection in a simulated office environment. https://doi.org/10.1016/j.jbi.2023.104299

DOI: 10.1016/j.jbi.2023.104299

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[26]other peer reviewed

Charles H. Hillman, Erin M. Snook, Gerald J. Jerome (2003). Acute cardiovascular exercise and executive control function. https://doi.org/10.1016/s0167-8760(03)00080-1

DOI: 10.1016/s0167-8760(03)00080-1

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[27]other peer reviewed

Tröndle I, Westernströer B, Wistuba J, Terwort N, Schlatt S, Neuhaus N (2017). Irradiation affects germ and somatic cells in prepubertal monkey testis xenografts.. https://doi.org/10.1093/molehr/gax003

DOI: 10.1093/molehr/gax003

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[28]other peer reviewed

I‐Hua Chen, Hsin‐Pao Chen, Jeffrey Hugh Gamble, Xiao ling Liao, Xiu‐Mei Chen, Yating Yang (2022). Evaluating a cross-lagged panel model between problematic internet use and psychological distress and cross-level mediation of school administrator support on problematic internet use: The serial mediating role of psychological needs thwarting of online teaching and psychological distress. https://doi.org/10.3389/fpubh.2022.987366

DOI: 10.3389/fpubh.2022.987366

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[29]other peer reviewed

Hu Yu, Luo Nan Jian, Gan Lu, Xue Hong Yan, Luo Ke Yan, Zhang Jiao Jiao (2024). Heat stress upregulates arachidonic acid to trigger autophagy in sertoli cells via dysfunctional mitochondrial respiratory chain function.. https://doi.org/10.1186/s12967-024-05182-y

DOI: 10.1186/s12967-024-05182-y

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[30]observational

Naser Abdallah Y, Dahmash Eman Zmaily, Al-Rousan Rabaa, Alwafi Hassan, Alrawashdeh Hamzeh Mohammad, Ghoul Imene (2020). Mental health status of the general population, healthcare professionals, and university students during 2019 coronavirus disease outbreak in Jordan: A cross-sectional study.. https://doi.org/10.1002/brb3.1730

DOI: 10.1002/brb3.1730

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[31]observational

Matthew J. Savage, P. J. Hennis, Daniele Magistro, James A. Donaldson, Laura C. Healy, Ruth M. James (2021). Nine Months into the COVID-19 Pandemic: A Longitudinal Study Showing Mental Health and Movement Behaviours Are Impaired in UK Students. https://doi.org/10.3390/ijerph18062930

DOI: 10.3390/ijerph18062930

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[32]observational

Teng Zhang, Meilin Liu, Fanli Min, Wei Wei, Yuan Liu, Tong Jiao (2023). Fear of childbirth and its determinants in pregnant women in the third trimester: a cross-sectional study. https://doi.org/10.1186/s12888-023-05070-7

DOI: 10.1186/s12888-023-05070-7

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[33]other peer reviewed

Belyeu Jonathan R, Brand Harrison, Wang Harold, Zhao Xuefang, Pedersen Brent S, Feusier Julie (2021). De novo structural mutation rates and gamete-of-origin biases revealed through genome sequencing of 2,396 families.. https://doi.org/10.1016/j.ajhg.2021.02.012

DOI: 10.1016/j.ajhg.2021.02.012

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[34]other peer reviewed

Stamatiadis P, Cosemans G, Boel A, Menten B, De Sutter P, Stoop D (2022). TEAD4 regulates trophectoderm differentiation upstream of CDX2 in a GATA3-independent manner in the human preimplantation embryo.. https://doi.org/10.1093/humrep/deac138

DOI: 10.1093/humrep/deac138

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[35]other peer reviewed

Chen Chen, Qi Hongjian, Shen Yufeng, Pickrell Joseph, Przeworski Molly, Hongjian Qi (2017). Contrasting Determinants of Mutation Rates in Germline and Soma.. https://doi.org/10.1534/genetics.117.1114

DOI: 10.1534/genetics.117.1114

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[36]randomized controlled trial

Roberto Bernabei, Francesco Landi, Riccardo Calvani, Matteo Cesari, Susanna Del Signore, Stefan D. Anker (2022). Multicomponent intervention to prevent mobility disability in frail older adults: randomised controlled trial (SPRINTT project). https://doi.org/10.1136/bmj-2021-068788

DOI: 10.1136/bmj-2021-068788

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[37]other peer reviewed

Arbeithuber Barbara, Hester James, Cremona Marzia A, Stoler Nicholas, Zaidi Arslan, Higgins Bonnie (2020). Age-related accumulation of de novo mitochondrial mutations in mammalian oocytes and somatic tissues.. https://doi.org/10.1371/journal.pbio.3000745

DOI: 10.1371/journal.pbio.3000745

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[38]other peer reviewed

Salfi Federico, Lauriola Marco, D'Atri Aurora, Amicucci Giulia, Viselli Lorenzo, Tempesta Daniela (2021). Demographic, psychological, chronobiological, and work-related predictors of sleep disturbances during the COVID-19 lockdown in Italy.. https://doi.org/10.1038/s41598-021-90993-y

DOI: 10.1038/s41598-021-90993-y

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[39]observational

Sukhpreet K. Tamana, Victor E. Ezeugwu, Joyce Chikuma, Diana L. Lefebvre, Meghan B. Azad, Theo J. Moraes (2019). Screen-time is associated with inattention problems in preschoolers: Results from the CHILD birth cohort study. https://doi.org/10.1371/journal.pone.0213995

DOI: 10.1371/journal.pone.0213995

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[40]other peer reviewed

Renato Pisanti, Maria Pia Gagliardi, Simona Razzino, Mario Bertini (2003). Occupational Stress and Wellness Among Italian Secondary School Teachers. https://doi.org/10.1080/0887044031000147247

DOI: 10.1080/0887044031000147247

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[41]other peer reviewed

Julie Bernhardt, Helen M. Dewey, Amanda G. Thrift, Janice Collier, Geoffrey A. Donnan (2008). A Very Early Rehabilitation Trial for Stroke (AVERT). https://doi.org/10.1161/strokeaha.107.492363

DOI: 10.1161/strokeaha.107.492363

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[42]other peer reviewed

Yuki Yamaguchi, Hirotaka Shibata, Hiroshi Handa (2012). Transcription elongation factors DSIF and NELF: Promoter-proximal pausing and beyond. https://doi.org/10.1016/j.bbagrm.2012.11.007

DOI: 10.1016/j.bbagrm.2012.11.007

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[43]other peer reviewed

Yijing Xiao, Burçin Becerik-Gerber, Gale Lucas, Shawn C. Roll (2020). Impacts of Working From Home During COVID-19 Pandemic on Physical and Mental Well-Being of Office Workstation Users. https://doi.org/10.1097/jom.0000000000002097

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[44]other peer reviewed

Matthew S. Ganio, Lawrence E. Armstrong, Douglas J. Casa, Brendon P. McDermott, Elaine C. Lee, Linda M. Yamamoto (2011). Mild dehydration impairs cognitive performance and mood of men. https://doi.org/10.1017/s0007114511002005

DOI: 10.1017/s0007114511002005

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[45]other peer reviewed

Chuan‐Chung Hsieh, Sophia Shi-Huei Ho, Hui-Chieh Li, Jyun‐Kai Liang (2021). Mindfulness as Moderator Against Emotional Exhaustion Due to Online Teaching During COVID-19 Pandemic: An Investigation Using Job Demands-Resources Model and Conservation of Resource Theory. https://doi.org/10.3389/fpsyg.2021.781804

DOI: 10.3389/fpsyg.2021.781804

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[46]observational

Magnavita Nicola, Tripepi Giovanni, Di Prinzio Reparata Rosa (2020). Symptoms in Health Care Workers during the COVID-19 Epidemic. A Cross-Sectional Survey.. https://doi.org/10.3390/ijerph17145218

DOI: 10.3390/ijerph17145218

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[47]other peer reviewed

Zhou Ning, Xu Yuanyuan, Huang Yumin, Ye Guoxiang, Luo Liang, Song Zuodong (2025). Comprehensive genomic profiling of Chinese lung cancer characterizes germline-somatic mutation interactions influencing cancer risk.. https://doi.org/10.1186/s12967-025-06096-z

DOI: 10.1186/s12967-025-06096-z

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[48]other peer reviewed

Jacqueline L. Reynolds, Colin G. Drury, Richard L. Broderick (1994). A field methodology for the control of musculoskeletal injuries. https://doi.org/10.1016/0003-6870(94)90025-6

DOI: 10.1016/0003-6870(94)90025-6

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[49]other peer reviewed

Kazyken Dubek, Dame Sydney G, Wang Claudia, Wadley Maxwell, Fingar Diane C (2024). Unexpected roles for AMPK in the suppression of autophagy and the reactivation of MTORC1 signaling during prolonged amino acid deprivation.. https://doi.org/10.1080/15548627.2024.2355074

DOI: 10.1080/15548627.2024.2355074

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[50]other peer reviewed

Petricca Sabrina, Flati Vincenzo, Celenza Giuseppe, Di Gregorio Jacopo, Lizzi Anna Rita, Luzi Carla (2019). Tebuconazole and Econazole Act Synergistically in Mediating Mitochondrial Stress, Energy Imbalance, and Sequential Activation of Autophagy and Apoptosis in Mouse Sertoli TM4 Cells: Possible Role of AMPK/ULK1 Axis.. https://doi.org/10.1093/toxsci/kfz031

DOI: 10.1093/toxsci/kfz031

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